Dimethylformamide → {6-[1-(2,4-Dimethyl-thiazole-5-sulfonyl)piperidin-4-yloxy]-5-nitro-pyrimidin-4-yl}-(4-methanesulfonyl-phenyl)-amine

HRID 832578Notes

Reaction equation

HRID 832578 reaction equation
[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([NH:11][c:12]2[n:13][cH:14][n:15][c:16]([O:21][CH:22]3[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]3)[c:17]2[N+:18](=[O:19])[O-:20])[cH:9][cH:10]1.[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH3:34].[CH3:35][c:36]1[s:37][c:38]([S:42](=[O:43])(=[O:44])[Cl:45])[c:39]([CH3:41])[n:40]1.[O:46]=[CH:47][N:48]([CH3:49])[CH3:50]>>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([NH:11][c:12]2[n:13][cH:14][n:15][c:16]([O:21][CH:22]3[CH2:23][CH2:24][N:25]([S:42]([c:38]4[s:37][c:36]([CH3:35])[n:40][c:39]4[CH3:41])(=[O:43])=[O:44])[CH2:26][CH2:27]3)[c:17]2[N+:18](=[O:19])[O-:20])[cH:9][cH:10]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 2776248Dimethyl-1,3-thiazole-5-sulfonyl chlorideHCID 11257886(4-Methanesulfonyl-phenyl)-[5-nitro-6-(piperidin-4-yloxy)-pyrimidin-4-yl]-amine

Product 1

HCID 59856716{6-[1-(2,4-Dimethyl-thiazole-5-sulfonyl)piperidin-4-yloxy]-5-nitro-pyrimidin-4-yl}-(4-methanesulfonyl-phenyl)-amine

Sources & evidence

ORD record
ord-d3f5932407ed4189a3ac285e15eb6139
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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