Hydrochloric Acid → 3-(4-t-Butyl-phenyl)-N-(2,5-difluoro-4-methanesulfonylamino-benzyl)-acrylamide

HRID 833129Notes

Reaction equation

HRID 833129 reaction equation
[C:17]([CH3:18])([CH3:19])([CH3:20])[c:21]1[cH:22][cH:23][c:24]([CH:27]=[CH:28][C:29](=[O:30])[OH:31])[cH:25][cH:26]1.[ClH:1].[NH2:2][CH2:3][c:4]1[cH:5][c:6]([F:16])[c:7]([NH:11][S:12](=[O:13])(=[O:14])[CH3:15])[cH:8][c:9]1[F:10].[O:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1>>[NH:2]([CH2:3][c:4]1[cH:5][c:6]([F:16])[c:7]([NH:11][S:12](=[O:13])(=[O:14])[CH3:15])[cH:8][c:9]1[F:10])[C:29]([CH:28]=[CH:27][c:24]1[cH:23][cH:22][c:21]([C:17]([CH3:18])([CH3:19])[CH3:20])[cH:26][cH:25]1)=[O:30]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 7248384-Tert-butylcinnamic acidHCID 66857102N-[4-(aminomethyl)-2,5-difluorophenyl]methanesulfonamide

Product 1

HCID 672425043-(4-t-Butyl-phenyl)-N-(2,5-difluoro-4-methanesulfonylamino-benzyl)-acrylamide

Sources & evidence

ORD record
ord-1bf9394a6ee04dbeafd1f2ceddaec088
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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