Hydrochloric Acid → N-[[2-chloro-4-fluoro-3-(trifluoromethyl)phenyl]methyl]-1-methyl-5-oxopyrrolidine-2-carboxamide

HRID 833414Notes

Reaction equation

HRID 833414 reaction equation
[C:44](=[O:45])([O-:46])[OH:47].[CH2:11]([O:12][CH:13]1[CH:14]=[CH:15][c:16]2[c:17]([cH:18][cH:19][cH:20][cH:21]2)[N:22]1[C:23]([O:24][CH2:25][CH3:26])=[O:27])[CH3:28].[CH3:1][N:2]1[CH:3]([C:4](=[O:5])[OH:6])[CH2:7][CH2:8][C:9]1=[O:10].[Cl:30][c:31]1[c:32]([CH2:42][NH2:43])[cH:33][cH:34][c:35]([F:41])[c:36]1[C:37]([F:38])([F:39])[F:40].[Cl:49][CH2:50][Cl:51].[ClH:29].[Na+:48]>>[CH3:1][N:2]1[CH:3]([C:4](=[O:6])[NH:43][CH2:42][c:32]2[c:31]([Cl:30])[c:36]([C:37]([F:38])([F:39])[F:40])[c:35]([F:41])[cH:34][cH:33]2)[CH2:7][CH2:8][C:9]1=[O:10]

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 923Sodium ionHCID 6344DichloromethaneHCID 278332-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinolineHCID 134586341-methyl-5-oxo-DL-prolineHCID 86617539[2-Chloro-4-fluoro-3-(trifluoromethyl)phenyl]methanamine

Product 1

HCID 59303353N-[[2-chloro-4-fluoro-3-(trifluoromethyl)phenyl]methyl]-1-methyl-5-oxopyrrolidine-2-carboxamide

Sources & evidence

ORD record
ord-e11f9afd1c45401cafc7b7bc4843e597
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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