Hydrochloric Acid → 6-[4-[2-Fluoro-4-[5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperazin-1-yl]pyridazine-3-carbonitrile

HRID 833742Notes

Reaction equation

HRID 833742 reaction equation
[CH3:23][CH2:24][N:25]([CH2:26][CH3:27])[CH2:28][CH3:29].[CH3:39][C:40]#[N:41].[Cl:30][c:31]1[n:32][n:33][c:34]([C:37]#[N:38])[cH:35][cH:36]1.[ClH:1].[F:2][c:3]1[cH:4][c:5]([N:15]2[C:16](=[O:22])[O:17][CH:18]([CH2:20][OH:21])[CH2:19]2)[cH:6][cH:7][c:8]1[N:9]1[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]1>>[F:2][c:3]1[cH:4][c:5]([N:15]2[C:16](=[O:22])[O:17][CH:18]([CH2:20][OH:21])[CH2:19]2)[cH:6][cH:7][c:8]1[N:9]1[CH2:10][CH2:11][N:12]([c:31]2[n:32][n:33][c:34]([C:37]#[N:38])[cH:35][cH:36]2)[CH2:13][CH2:14]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 6342AcetonitrileHCID 8471TriethylamineHCID 133828716-Chloropyridazine-3-carbonitrileHCID 229436273-(3-Fluoro-4-piperazin-1-ylphenyl)-5-(hydroxymethyl)-1,3-oxazolidin-2-one

Product 1

HCID 229959426-[4-[2-Fluoro-4-[5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperazin-1-yl]pyridazine-3-carbonitrile

Sources & evidence

ORD record
ord-378a735d29c241d2a8b43f376a753ece
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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