Chloride → (4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-(4-chloro-5-fluoro-2-methoxy-phenyl)-methanone

HRID 834006Notes

Reaction equation

HRID 834006 reaction equation
[CH3:17][O:18][N:19]([C:20](=[O:21])[c:22]1[c:23]([NH2:31])[n:24][c:25]([S:28][CH2:29][CH3:30])[n:26][cH:27]1)[CH3:32].[CH:13]([Mg+:14])([CH3:15])[CH3:16].[Cl-:12].[Cl:1][c:2]1[c:3]([F:11])[cH:4][c:5]([I:10])[c:6]([O:8][CH3:9])[cH:7]1.[O:33]1[CH2:34][CH2:35][CH2:36][CH2:37]1>>[Cl:1][c:2]1[c:3]([F:11])[cH:4][c:5]([C:20](=[O:21])[c:22]2[c:23]([NH2:31])[n:24][c:25]([S:28][CH2:29][CH3:30])[n:26][cH:27]2)[c:6]([O:8][CH3:9])[cH:7]1

Participants

6

Reactant 5

HCID 312ChlorideHCID 8028TetrahydrofuranHCID 119748325-Pyrimidinecarboxamide, 4-amino-2-(ethylthio)-N-methoxy-N-methyl-HCID 210706301-Chloro-2-fluoro-4-iodo-5-methoxybenzeneHCID 178461726HCID 178461726, compound

Product 1

HCID 21070583(4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-(4-chloro-5-fluoro-2-methoxy-phenyl)-methanone

Sources & evidence

ORD record
ord-32c854f3b77f41c087e1ae59636534b0
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…