Dimethylformamide → (+/-)-2-[3-chloro-4-[(4-chlorophenyl)(4-hydroxy-1-piperidinyl) methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione

HRID 834044Notes

Reaction equation

HRID 834044 reaction equation
[Cl:1][c:2]1[cH:3][c:4](-[n:17]2[n:18][cH:19][c:20](=[O:24])[nH:21][c:22]2=[O:23])[cH:5][cH:6][c:7]1[CH:8]([c:9]1[cH:10][cH:11][c:12]([Cl:15])[cH:13][cH:14]1)[Cl:16].[O:32]=[CH:33][N:34]([CH3:35])[CH3:36].[OH:25][CH:26]1[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]1>>[Cl:1][c:2]1[cH:3][c:4](-[n:17]2[n:18][cH:19][c:20](=[O:24])[nH:21][c:22]2=[O:23])[cH:5][cH:6][c:7]1[CH:8]([c:9]1[cH:10][cH:11][c:12]([Cl:15])[cH:13][cH:14]1)[N:29]1[CH2:28][CH2:27][CH:26]([OH:25])[CH2:31][CH2:30]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 79341Piperidin-4-olHCID 225573573-chloro-4-[chloro(4-chlorophenyl)methyl]phenyl-1,2,4-triazine-3,5(2H,4H)-dione

Product 1

HCID 22557329(+/-)-2-[3-chloro-4-[(4-chlorophenyl)(4-hydroxy-1-piperidinyl) methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione

Sources & evidence

ORD record
ord-28b94f0f8e734d85b7a524569d88bd3a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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