Tetrahydrofuran → 3-(7-bromo-1,2,3,4-tetrahydro-naphthalen-1-yl)-3H-imidazole-4-carboxylic acid isopropyl ester

HRID 834325Notes

Reaction equation

HRID 834325 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:10]([cH:11]1)[CH:9]([OH:12])[CH2:8][CH2:7][CH2:6]2.[CH2:53]1[O:54][CH2:55][CH2:56][CH2:57]1.[N:43]([C:44]([O:45][CH3:46])=[O:47])=[N:48][C:49]([O:50][CH3:51])=[O:52].[c:24]1([P:25]([c:26]2[cH:27][cH:28][cH:29][cH:30][cH:31]2)[c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[cH:38][cH:39][cH:40][cH:41][cH:42]1.[nH:13]1[cH:14][n:15][c:16]([C:18](=[O:19])[O:20][CH:21]([CH3:22])[CH3:23])[cH:17]1>>[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:10]([cH:11]1)[CH:9]([n:15]1[cH:14][n:13][cH:17][c:16]1[C:18](=[O:19])[O:20][CH:21]([CH3:22])[CH3:23])[CH2:8][CH2:7][CH2:6]2

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 351621Azodicarboxylic acid dimethyl esterHCID 126949197-Bromo-1,2,3,4-tetrahydronaphthalen-1-olHCID 178459416HCID 178459416, compound

Product 1

HCID 591994563-(7-bromo-1,2,3,4-tetrahydro-naphthalen-1-yl)-3H-imidazole-4-carboxylic acid isopropyl ester

Sources & evidence

ORD record
ord-dfd2eb3f5f8a473a81103344b9cebd0e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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