HRID8344

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID79040

Propanoic acid, 2-bromo-, ethyl ester

C5H9BrO2

结构：Oc1ccc(-c2nnnc(-c3cccc4ccccc34)c2-c2cccc3ccccc23)c(O)c1

HCID136338648

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C(C)Oc1ccc(-c2nnnc(-c3cccc4ccccc34)c2-c2cccc3ccccc23)c(O)c1

HCID136338649

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度: 125 °C

PROCEDURE

实验过程

9.39 g of potassium carbonate and 9.02 g of 2-bromopropionic acid ethyl ester are added to a solution of 20.0 g of the product from Example A6 in 200 ml of DMF. The reaction mixture is heated at 125° C. for 3.5 h. The solid which precipitates is filtered off and washed with toluene. The combined organic phase is freed of solvent in vac. Chromatography of the residue on silica gel yields the product of melting point: 124–125° C.

WORKUP

后处理

customThe solid which precipitates
filtrationis filtered off
washwashed with toluene
customChromatography of the residue on silica gel yields the product of melting point: 124–125° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-692c51953fd446438dbb2938ec9d651f
来源数据集: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07087753B2
来源说明: uspto-grants-2006_08

反应 SMILES

C(=O)([O-])[O-].[K+].[K+].[CH2:7]([O:9][C:10](=[O:14])[CH:11](Br)[CH3:12])[CH3:8].[C:15]1([C:25]2[N:30]=[N:29][N:28]=[C:27]([C:31]3[CH:36]=[CH:35][C:34]([OH:37])=[CH:33][C:32]=3[OH:38])[C:26]=2[C:39]2[C:48]3[C:43](=[CH:44][CH:45]=[CH:46][CH:47]=3)[CH:42]=[CH:41][CH:40]=2)[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[CH:17][CH:16]=1>CN(C=O)C>[C:15]1([C:25]2[N:30]=[N:29][N:28]=[C:27]([C:31]3[CH:36]=[CH:35][C:34]([O:37][CH:11]([C:10]([O:9][CH2:7][CH3:8])=[O:14])[CH3:12])=[CH:33][C:32]=3[OH:38])[C:26]=2[C:39]2[C:48]3[C:43](=[CH:44][CH:45]=[CH:46][CH:47]=3)[CH:42]=[CH:41][CH:40]=2)[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[CH:17][CH:16]=1