Acetonitrile → tert-butyl 5-bromo-2,3-dihydro-1H-indole-1-carboxylate

HRID 834543Notes

Reaction equation

HRID 834543 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[NH:7][CH2:6][CH2:5]2.[C:11]([CH3:12])([CH3:13])([CH3:14])[O:15][C:16]([O:17][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:18].[CH3:23][C:24]#[N:25].[CH3:26][N:27]([CH3:28])[c:29]1[cH:30][cH:31][n:32][cH:33][cH:34]1.[CH3:35][CH2:36][O:37][C:38]([CH3:39])=[O:40]>>[Br:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[N:7]([C:16]([O:15][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:17])[CH2:6][CH2:5]2

Participants

6

Reactant 5

HCID 6342AcetonitrileHCID 8857Ethyl AcetateHCID 142844-(Dimethylamino)pyridineHCID 34115665-BromoindolineHCID 10219638Carbonic acid, bis(1,1-dimethylethyl) ester

Product 1

HCID 21865438tert-butyl 5-bromo-2,3-dihydro-1H-indole-1-carboxylate

Sources & evidence

ORD record
ord-9eb6d338247a4fc5967caeecc11d033b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…