反应详情

温度

80 °C

To an optically active compound of 1-(2,4-dimethoxybenzyl)-5-oxopyrrolidine-3-carboxylic acid (14.3 g) were added anisole (8.4 ml) and trifluoroacetic acid (100 ml), and the mixture was stirred at 80° C. for 5 hours. This reaction solution was cooled to room temperature, and concentrated under reduced pressure. To the resulting residue was added diisopropyl ether (100 ml), and the mixture was stirred at room temperature. The insoluble substance was collected by filtration, washed with diisopropyl ether, and dried under reduced pressure to give the titled compound (4.96 g).

1. temperatureThis reaction solution was cooled to room temperature
2. concentrationconcentrated under reduced pressure
3. additionTo the resulting residue was added diisopropyl ether (100 ml)
4. stirringthe mixture was stirred at room temperature
5. filtrationThe insoluble substance was collected by filtration
6. washwashed with diisopropyl ether
7. customdried under reduced pressure