反应详情

温度

80 °C

To an optically active compound of 1-(2,4-dimethoxybenzyl)-6-oxopiperidine-3-carboxylic acid (1.36 g) were added anisole (758 μl) and trifluoroacetic acid (10 ml), and the mixture was stirred at 80° C. for 6 hours. This reaction solution was cooled to room temperature, and then concentrated under reduced pressure. To the resulting residue was added diisopropyl ether, and the mixture was stirred at room temperature. The insoluble substance was collected by filtration, and dried under reduced pressure to give the titled compound (628 mg).

1. temperatureThis reaction solution was cooled to room temperature
2. concentrationconcentrated under reduced pressure
3. additionTo the resulting residue was added diisopropyl ether
4. stirringthe mixture was stirred at room temperature
5. filtrationThe insoluble substance was collected by filtration
6. customdried under reduced pressure