反应详情

To (S)-1-(2,4-dimethoxybenzyl)-5-oxopyrrolidine-3-carboxylic acid (5.3 g) were added anisole (3.1 ml) and trifluoroacetic acid (26.5 ml) at room temperature, and the mixture was stirred for 4 hours at reflux. This reaction solution was cooled to room temperature, concentrated under reduced pressure, azeotropic-dried with toluene. To the resulting residue was added diisopropyl ether (53 ml), and the mixture was stirred at room temperature. A solid was collected from this suspension by filtration, washed with diisopropyl ether, and dried under reduced pressure to give the titled compound (2.4 g).

1. temperatureat reflux
2. concentrationconcentrated under reduced pressure
3. dry with materialazeotropic-dried with toluene
4. additionTo the resulting residue was added diisopropyl ether (53 ml)
5. stirringthe mixture was stirred at room temperature
6. filtrationA solid was collected from this suspension by filtration
7. washwashed with diisopropyl ether
8. customdried under reduced pressure