Methanol → 4-((2-hydroxyethyl)(phenyl)amino)-N,N-dimethyl-2-(4-(oxazol-5-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide

HRID 835315Notes

Reaction equation

HRID 835315 reaction equation
[CH3:33][CH2:34][N:35]([CH2:36][CH3:37])[CH2:38][CH3:39].[CH3:40][N:41]([C:42](=[O:43])[Cl:44])[CH3:45].[CH3:49][OH:50].[Cl:46][CH2:47][Cl:48].[o:1]1[cH:2][n:3][cH:4][c:5]1-[c:6]1[cH:7][cH:8][c:9]([NH:12][c:13]2[n:14][c:15]([N:23]([CH2:24][CH2:25][OH:26])[c:27]3[cH:28][cH:29][cH:30][cH:31][cH:32]3)[c:16]3[c:17]([n:18]2)[CH2:19][CH2:20][NH:21][CH2:22]3)[cH:10][cH:11]1>>[o:1]1[cH:2][n:3][cH:4][c:5]1-[c:6]1[cH:7][cH:8][c:9]([NH:12][c:13]2[n:14][c:15]([N:23]([CH2:24][CH2:25][OH:26])[c:27]3[cH:28][cH:29][cH:30][cH:31][cH:32]3)[c:16]3[c:17]([n:18]2)[CH2:19][CH2:20][N:21]([C:42]([N:41]([CH3:40])[CH3:45])=[O:43])[CH2:22]3)[cH:10][cH:11]1

Participants

6

Reactant 5

HCID 887MethanolHCID 6344DichloromethaneHCID 6598Dimethylcarbamoyl ChlorideHCID 8471TriethylamineHCID 462000502-((2-(4-(Oxazol-5-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)(phenyl)amino)ethanol

Product 1

HCID 462006704-((2-hydroxyethyl)(phenyl)amino)-N,N-dimethyl-2-(4-(oxazol-5-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide

Sources & evidence

ORD record
ord-de43e960c464482fa19be668d6f4e488
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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