反应详情

温度

80 °C

To an optically active compound of 5-(2,4-dimethoxybenzyl)-4-oxo-5-azaspiro[2.4]heptane-7-carboxylic acid (372 mg) were sequentially added anisole (159 μl) and trifluoroacetic acid (5.6 ml) at room temperature, and the mixture was stirred at 80° C. for 4 hours. This reaction mixture was concentrated under reduced pressure, and diisopropyl ether (10 ml) was added thereto. The precipitated solid was collected by filtration to give the titled compound (144 mg).

1. customat room temperature
2. concentrationThis reaction mixture was concentrated under reduced pressure, and diisopropyl ether (10 ml)
3. additionwas added
4. filtrationThe precipitated solid was collected by filtration