Benzaldehyde → 3-phenyl-5-(beta-hydroxyphenethyl)-N-methyl-isoxazole-4-carboxamide

HRID 836339Notes

Reaction equation

HRID 836339 reaction equation
[CH2:17]([Li:18])[CH2:19][CH2:20][CH3:21].[CH3:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27].[CH:28](=[O:29])[c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1.[O:36]1[CH2:37][CH2:38][CH2:39][CH2:40]1.[c:1]1(-[c:7]2[n:8][o:9][c:10]([CH3:16])[c:11]2[C:12](=[O:13])[NH:14][CH3:15])[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1(-[c:7]2[n:8][o:9][c:10]([CH2:16][CH:28]([OH:29])[c:30]3[cH:31][cH:32][cH:33][cH:34][cH:35]3)[c:11]2[C:12](=[O:13])[NH:14][CH3:15])[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

6

Reactant 5

HCID 240BenzaldehydeHCID 8028TetrahydrofuranHCID 8058HexaneHCID 4104650N,5-Dimethyl-3-phenyl-4-isoxazolecarboxamideHCID 178418339Butyllithium

Product 1

HCID 203050053-phenyl-5-(beta-hydroxyphenethyl)-N-methyl-isoxazole-4-carboxamide

Sources & evidence

ORD record
ord-87b88384ace94f618acb543ba83c6820
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…