Dimethylformamide → 2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

HRID 836388Notes

Reaction equation

HRID 836388 reaction equation
[CH3:17][CH2:18][CH2:19][CH2:20][Li:21].[CH3:22][N:23]([CH:24]=[O:25])[CH3:26].[Cl:1][c:2]1[n:3][c:4]([N:11]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)[c:5]2[c:6]([n:7]1)[cH:8][cH:9][s:10]2.[O:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1>>[Cl:1][c:2]1[n:3][c:4]([N:11]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH:24]=[O:25])[s:10]2

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 202849712-Chloro-4-(morpholin-4-yl)thieno(3,2-d)pyrimidineHCID 178418339Butyllithium

Product 1

HCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

Sources & evidence

ORD record
ord-7af66435d516491c97d93766416c2816
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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