Ammonium → Ethyl 1-benzyl-5,5-difluoro-4-oxopiperidine-3-carboxylate

HRID 836540Notes

Reaction equation

HRID 836540 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]([CH2:9][C:10]([C:11]([O:13][CH2:12][CH3:14])=[O:15])([F:16])[F:17])[CH2:18][CH2:19][C:20](=[O:21])[O:22][CH2:23][CH3:24].[CH3:25][C:26]([CH3:27])([O-:28])[CH3:29].[CH3:33][N:34]1[CH2:35][CH2:36][CH2:37][C:38]1=[O:39].[Cl-:31].[K+:30].[NH4+:32]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][C:10]([F:16])([F:17])[C:11](=[O:13])[CH:19]([C:20](=[O:21])[O:22][CH2:23][CH3:24])[CH2:18]1

Participants

7

Reactant 6

HCID 223AmmoniumHCID 312ChlorideHCID 813Potassium CationHCID 13387N-methyl-2-pyrrolidoneHCID 45749132-Methylpropan-2-olateHCID 59442745Ethyl 3-(benzyl(3-ethoxy-3-oxopropyl)amino)-2,2-difluoropropanoate

Product 1

HCID 49761228Ethyl 1-benzyl-5,5-difluoro-4-oxopiperidine-3-carboxylate

Sources & evidence

ORD record
ord-c36e48b8a307438ba5c231642f633349
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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