Citric Acid → 2-(2-Pyridylmethoxy)-4-(3-chloro-4-methoxybenzylamino)-5-ethoxycarbonylpyrimidine

HRID 836542Notes

Reaction equation

HRID 836542 reaction equation
[CH3:11][S:12](=[O:13])(=[O:14])[c:15]1[n:16][cH:17][c:18]([C:32](=[O:33])[O:34][CH2:35][CH3:36])[c:19]([NH:21][CH2:22][c:23]2[cH:24][c:25]([Cl:31])[c:26]([O:29][CH3:30])[cH:27][cH:28]2)[n:20]1.[H-:9].[Na+:10].[O:37]1[CH2:38][CH2:39][CH2:40][CH2:41]1.[OH:1][CH2:2][c:3]1[n:4][cH:5][cH:6][cH:7][cH:8]1.[OH:42][C:43]([CH2:44][C:45]([C:46](=[O:47])[OH:48])([CH2:49][C:50](=[O:51])[OH:52])[OH:53])=[O:54]>>[O:1]([CH2:2][c:3]1[n:4][cH:5][cH:6][cH:7][cH:8]1)[c:15]1[n:16][cH:17][c:18]([C:32](=[O:33])[O:34][CH2:35][CH3:36])[c:19]([NH:21][CH2:22][c:23]2[cH:24][c:25]([Cl:31])[c:26]([O:29][CH3:30])[cH:27][cH:28]2)[n:20]1

Participants

7

Reactant 6

HCID 311Citric AcidHCID 923Sodium ionHCID 8028TetrahydrofuranHCID 11474PiconolHCID 166653HydrideHCID 17848304Ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylsulfonyl)pyrimidine-5-carboxylate

Product 1

HCID 178483472-(2-Pyridylmethoxy)-4-(3-chloro-4-methoxybenzylamino)-5-ethoxycarbonylpyrimidine

Sources & evidence

ORD record
ord-9ec6748028734899975f86bc1dbc3120
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…