Chloride → 4-(4-Benzyl-4-hydroxy-1-piperidinyl)benzonitrile

HRID 836926Notes

Reaction equation

HRID 836926 reaction equation
[CH2:25]1[O:26][CH2:27][CH2:28][CH2:29]1.[CH2:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[Mg+:9].[Cl-:1].[O:10]=[C:11]1[CH2:12][CH2:13][N:14]([c:17]2[cH:18][cH:19][c:20]([C:21]#[N:22])[cH:23][cH:24]2)[CH2:15][CH2:16]1>>[CH2:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[C:11]1([OH:10])[CH2:12][CH2:13][N:14]([c:17]2[cH:18][cH:19][c:20]([C:21]#[N:22])[cH:23][cH:24]2)[CH2:15][CH2:16]1

Participants

5

Reactant 4

HCID 312ChlorideHCID 8028TetrahydrofuranHCID 110198874-(4-Oxopiperidin-1-yl)benzonitrileHCID 178507042HCID 178507042, compound

Product 1

HCID 591866274-(4-Benzyl-4-hydroxy-1-piperidinyl)benzonitrile

Sources & evidence

ORD record
ord-bff4581abdd64d94b065aff4975efb91
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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