N-methyl-2-pyrrolidone → Methyl 7-(4-((4-chlorophenethyl)carbamoyl)phenoxy)-3,4-dihydro-2H-chromene-4-carboxylate

HRID 836941Notes

Reaction equation

HRID 836941 reaction equation
[C:48](=[O:49])([O-:50])[O-:51].[CH3:35][C:36]([CH3:37])([C:38](=[O:39])[CH2:40][C:41](=[O:42])[C:43]([CH3:44])([CH3:45])[CH3:46])[CH3:47].[CH3:54][N:55]1[CH2:56][CH2:57][CH2:58][C:59]1=[O:60].[Cl:16][c:17]1[cH:18][cH:19][c:20]([CH2:21][CH2:22][NH:23][C:24]([c:25]2[cH:26][cH:27][c:28]([I:31])[cH:29][cH:30]2)=[O:32])[cH:33][cH:34]1.[Cs+:52].[Cs+:53].[Cu:61][Cl:62].[OH:1][c:2]1[cH:3][cH:4][c:5]2[c:10]([cH:11]1)[O:9][CH2:8][CH2:7][CH:6]2[C:12](=[O:13])[O:14][CH3:15]>>[O:1]([c:2]1[cH:3][cH:4][c:5]2[c:10]([cH:11]1)[O:9][CH2:8][CH2:7][CH:6]2[C:12](=[O:13])[O:14][CH3:15])[c:28]1[cH:27][cH:26][c:25]([C:24]([NH:23][CH2:22][CH2:21][c:20]2[cH:19][cH:18][c:17]([Cl:16])[cH:34][cH:33]2)=[O:32])[cH:30][cH:29]1

Participants

8

Reactant 7

HCID 13387N-methyl-2-pyrrolidoneHCID 19660Carbonate IonHCID 62652Cuprous chlorideHCID 707002,2,6,6-Tetramethyl-3,5-heptanedioneHCID 104967Cesium cation2×HCID 42965003N-(4-chlorophenethyl)-4-iodobenzamideHCID 67080454methyl 7-hydroxy-3,4-dihydro-2H-chromene-4-carboxylate

Product 1

HCID 67080596Methyl 7-(4-((4-chlorophenethyl)carbamoyl)phenoxy)-3,4-dihydro-2H-chromene-4-carboxylate

Sources & evidence

ORD record
ord-5be5d66046e04f1597865d009b086db0
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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