Hydrochloric Acid → 6-(Piperidin-4-yloxy)-4-(4,4,4-trifluoro-butyl)-isoquinoline

HRID 836942Notes

Reaction equation

HRID 836942 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[cH:16][c:17]3[c:18]([CH2:25][CH2:26][CH2:27][C:28]([F:29])([F:30])[F:31])[cH:19][n:20][cH:21][c:22]3[cH:23][cH:24]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH:33]([OH:34])([CH3:35])[CH3:36].[ClH:32]>>[NH:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[cH:16][c:17]3[c:18]([CH2:25][CH2:26][CH2:27][C:28]([F:29])([F:30])[F:31])[cH:19][n:20][cH:21][c:22]3[cH:23][cH:24]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 576468604-[4-(4,4,4-Trifluoro-butyl)-isoquinolin-6-yloxy]-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 576470696-(Piperidin-4-yloxy)-4-(4,4,4-trifluoro-butyl)-isoquinoline

Sources & evidence

ORD record
ord-cdd72fe8b6cc4ec398186bdb22e57c19
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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