Trifluoroacetic acid → 7-chloro-3-(3,5-dimethylphenyl)-6-(3-oxo-3-pyrrolidin-1-yl-propyl)-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one

HRID 837003Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[N:8]1[CH:9]([CH2:14][CH2:15][O:16][c:17]2[c:18](-[c:38]3[cH:39][c:40]([CH3:45])[cH:41][c:42]([CH3:44])[cH:43]3)[c:19](=[O:37])[nH:20][c:21]3[cH:22][c:23]([Cl:36])[c:24]([CH2:27][CH2:28][C:29]([N:30]4[CH2:31][CH2:32][CH2:33][CH2:34]4)=[O:35])[cH:25][c:26]23)[CH2:10][CH2:11][CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH3:46][O:47][c:48]1[cH:49][cH:50][cH:51][cH:52][cH:53]1.[OH:54][C:55]([C:56]([F:57])([F:58])[F:59])=[O:60]>>[NH:8]1[CH:9]([CH2:14][CH2:15][O:16][c:17]2[c:18](-[c:38]3[cH:39][c:40]([CH3:45])[cH:41][c:42]([CH3:44])[cH:43]3)[c:19](=[O:37])[nH:20][c:21]3[cH:22][c:23]([Cl:36])[c:24]([CH2:27][CH2:28][C:29]([N:30]4[CH2:31][CH2:32][CH2:33][CH2:34]4)=[O:35])[cH:25][c:26]23)[CH2:10][CH2:11][CH2:12][CH2:13]1

Participants

Reactant 3

HCID 6422Trifluoroacetic acid

HCID 7519Anisole

HCID 536595522-{2-[7-Chloro-3-(3,5-dimethylphenyl)-2-oxo-6-(3-oxo-3-pyrrolidin-1-yl-propyl)-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 221245057-chloro-3-(3,5-dimethylphenyl)-6-(3-oxo-3-pyrrolidin-1-yl-propyl)-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one

Sources & evidence

ORD record: ord-713e79648e7443038fa24ff49173ef69
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…