Dimethylformamide → 2-Methyl-N-{2-[4-(3-Pyrrolidin-1-yl-Propane-1-Sulfonyl)-Phenylamino]-Pyrimidin-5-yl}-5-(3-Trifluoromethyl-Benzoylamino)-Benzamide

HRID 837275Notes

Reaction equation

HRID 837275 reaction equation
[CH3:35][N:36]1[CH2:37][CH2:38][O:39][CH2:40][CH2:41]1.[Cl:24][c:25]1[n:26][c:27]([O:28][CH3:29])[n:30][c:31]([O:32][CH3:33])[n:34]1.[Cl:67][CH2:68][Cl:69].[F:1][C:2]([c:3]1[cH:4][c:5]([C:6](=[O:7])[NH:8][c:9]2[cH:10][cH:11][c:12]([CH3:18])[c:13]([C:14](=[O:15])[OH:16])[cH:17]2)[cH:19][cH:20][cH:21]1)([F:22])[F:23].[N:42]1([CH2:47][CH2:48][CH2:49][S:50](=[O:51])(=[O:52])[c:53]2[cH:54][cH:55][c:56]([NH:59][c:60]3[n:61][cH:62][c:63]([NH2:66])[cH:64][n:65]3)[cH:57][cH:58]2)[CH2:43][CH2:44][CH2:45][CH2:46]1.[O:70]=[CH:71][N:72]([CH3:73])[CH3:74]>>[F:1][C:2]([c:3]1[cH:4][c:5]([C:6](=[O:7])[NH:8][c:9]2[cH:10][cH:11][c:12]([CH3:18])[c:13]([C:14](=[O:16])[NH:66][c:63]3[cH:62][n:61][c:60]([NH:59][c:56]4[cH:55][cH:54][c:53]([S:50]([CH2:49][CH2:48][CH2:47][N:42]5[CH2:43][CH2:44][CH2:45][CH2:46]5)(=[O:51])=[O:52])[cH:58][cH:57]4)[n:65][cH:64]3)[cH:17]2)[cH:19][cH:20][cH:21]1)([F:22])[F:23]

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 79724-MethylmorpholineHCID 184502-Chloro-4,6-dimethoxy-1,3,5-triazineHCID 58748692N-[4-(3-Pyrrolidin-1-yl-propane-1-sulfonyl)-phenyl]-pyrimidine-2,5-diamineHCID 596527072-Methyl-5-{[3-(trifluoromethyl)benzoyl]amino}benzoic acid

Product 1

HCID 249599952-Methyl-N-{2-[4-(3-Pyrrolidin-1-yl-Propane-1-Sulfonyl)-Phenylamino]-Pyrimidin-5-yl}-5-(3-Trifluoromethyl-Benzoylamino)-Benzamide

Sources & evidence

ORD record
ord-fc7775d2eff1425d8dd22665d0d9f167
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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