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HRID83751

反应详情

EQUATION

反应方程式

HRID 83751 的结构方程式

REACTANTS

反应物

1
结构：COC(=O)c1ccc(NC(=O)C2(c3ccc4c(c3)OCO4)CC2)cc1-c1ccc(C(=O)N(C)C)cc1
HCID59206350

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)C(=O)c1ccc(-c2cc(NC(=O)C3(c4ccc5c(c4)OCO5)CC3)ccc2C(=O)O)cc1
HCID59205934

未命名化合物

收率 8%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

结构：O=C([O-])[O-].[K+].[K+]
溶剂HCID11430

Potassium Carbonate

CK2O3

PROCEDURE

实验过程

Methyl 5-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-4′-(dimethylcarbamoyl)biphenyl-2-carboxylate (84 mg, 0.20 mmol) was dissolved in DMF (2.0 mL) with 1M K2CO3 (1.0 mL) and irradiated in the microwave at 150° C. for 10 minutes. Purification by reverse phase HPLC yielded 5-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-4′-(dimethylcarbamoyl)-biphenyl-2-carboxylic acid (7.3 mg, 8%). ESI-MS m/z calc. 472.5. found 473.3 (M+1)+; retention time 2.79 minutes.

WORKUP

后处理

  1. customirradiated in the microwave at 150° C. for 10 minutes
  2. customPurification by reverse phase HPLC