Chloride → 5-{[2-Hydroxy-5-methoxy-2-(pentafluoroethyl)-4,4,7-trimethyl-1,2,3,4-tetrahydronaphthalen-1-yl]amino}-quinolin-2(1H)-one

HRID 837591Notes

Reaction equation

HRID 837591 reaction equation
[CH3:1][O:2][c:3]1[c:4]([C:10]([CH2:11][C:12]([CH:13]=[O:14])([C:15]([C:16]([F:17])([F:18])[F:19])([F:20])[F:21])[OH:22])([CH3:23])[CH3:24])[cH:5][cH:6][c:7]([CH3:9])[cH:8]1.[Cl-:40].[Cl-:41].[Cl-:42].[Cl-:43].[Cl:37][CH2:38][Cl:39].[NH2:25][c:26]1[c:27]2[cH:28][cH:29][c:30](=[O:36])[nH:31][c:32]2[cH:33][cH:34][cH:35]1.[Ti+4:44]>>[CH3:1][O:2][c:3]1[c:4]2[c:5]([cH:6][c:7]([CH3:9])[cH:8]1)[CH:13]([NH:25][c:26]1[c:27]3[cH:28][cH:29][c:30](=[O:36])[nH:31][c:32]3[cH:33][cH:34][cH:35]1)[C:12]([C:15]([C:16]([F:17])([F:18])[F:19])([F:20])[F:21])([OH:22])[CH2:11][C:10]2([CH3:23])[CH3:24]

Participants

6

Reactant 5

HCID 312Chloride4×HCID 6344DichloromethaneHCID 114942Titanium cation (4+)HCID 157190785-Amino-1,2-dihydroquinolin-2-oneHCID 179891614-(2-Methoxy-4-methylphenyl)-2-hydroxy-4-methyl-2-(pentafluoroethyl)pentanal

Product 1

HCID 865999285-{[2-Hydroxy-5-methoxy-2-(pentafluoroethyl)-4,4,7-trimethyl-1,2,3,4-tetrahydronaphthalen-1-yl]amino}-quinolin-2(1H)-one

Sources & evidence

ORD record
ord-b1a80646d57d421f93131f49d9781e8e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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