Sodium ion → 3-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl-

HRID 837994Notes

Reaction equation

HRID 837994 reaction equation
[CH:43]([OH:44])([CH3:45])[CH3:46].[F:19][c:20]1[c:21]([B:28]([OH:29])[OH:30])[c:22]([O:26][CH3:27])[cH:23][cH:24][cH:25]1.[NH2:1][c:2]1[c:3]([C:13](=[O:14])[NH:15][CH2:16][CH2:17][CH3:18])[n:4][n:5][c:6]2[c:7]([Br:12])[cH:8][cH:9][cH:10][c:11]12.[Na+:36].[Na+:37].[O-:38][C:39](=[O:40])[O-:41].[O:31]1[CH2:32][CH2:33][CH2:34][CH2:35]1.[OH2:42]>>[NH2:1][c:2]1[c:3]([C:13](=[O:14])[NH:15][CH2:16][CH2:17][CH3:18])[n:4][n:5][c:6]2[c:7](-[c:21]3[c:20]([F:19])[cH:25][cH:24][cH:23][c:22]3[O:26][CH3:27])[cH:8][cH:9][cH:10][c:11]12

Participants

8

Reactant 7

HCID 923Sodium ion2×HCID 962WaterHCID 3776IsopropanolHCID 8028TetrahydrofuranHCID 19660Carbonate IonHCID 3294524(2-Fluoro-6-methoxyphenyl)boronic acidHCID 140123264-Amino-8-bromo-N-propylcinnoline-3-carboxamide

Product 1

HCID 235818693-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl-

Sources & evidence

ORD record
ord-f6c656c52ca345ca9ed8ad816eb39551
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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