Acetic Acid → 4-(4-Chloro-2-fluoroanilino)-7-(2-methoxyethoxy)-6-nitroquinazoline

HRID 838029Notes

Reaction equation

HRID 838029 reaction equation
[CH3:2][O:3][CH2:4][CH2:5][OH:6].[CH3:31][C:32](=[O:33])[OH:34].[Cl:8][c:9]1[c:10]([N+:28](=[O:29])[O-:30])[cH:11][c:12]2[c:13]([NH:19][c:20]3[c:21]([F:27])[cH:22][c:23]([Cl:26])[cH:24][cH:25]3)[n:14][cH:15][n:16][c:17]2[cH:18]1.[ClH:7].[Na:1].[OH2:35]>>[CH3:2][O:3][CH2:4][CH2:5][O:6][c:9]1[c:10]([N+:28](=[O:29])[O-:30])[cH:11][c:12]2[c:13]([NH:19][c:20]3[c:21]([F:27])[cH:22][c:23]([Cl:26])[cH:24][cH:25]3)[n:14][cH:15][n:16][c:17]2[cH:18]1

Participants

7

Reactant 6

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 962WaterHCID 80192-MethoxyethanolHCID 5360545SodiumHCID 224782517-chloro-N-(4-chloro-2-fluorophenyl)-6-nitroquinazolin-4-amine

Product 1

HCID 187534234-(4-Chloro-2-fluoroanilino)-7-(2-methoxyethoxy)-6-nitroquinazoline

Sources & evidence

ORD record
ord-289cb257ff8f482abccaa79e90ea1767
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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