Tetrahydrofuran → Tert-Butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate

HRID 838293Notes

Reaction equation

HRID 838293 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[c:15]([C:20](=[O:21])[OH:22])[cH:16][cH:17][cH:18][cH:19]2)[CH2:12][CH2:13]1.[CH2:23]1[O:24][CH2:25][CH2:26][CH2:27]1.[CH3:28][CH2:29][O:30][C:31]([CH3:32])=[O:33]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[c:15]([CH2:20][OH:21])[cH:16][cH:17][cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 226223632-(1-((Tert-butoxy)carbonyl)piperidin-4-yl)benzoic acid

Product 1

HCID 57774474Tert-Butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-5de6aa0e6643498b87acf6810034d730
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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