Tetrahydrofuran → N-{5-[(2-Chloro-4-pyrimidinyl)acetyl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

HRID 838652Notes

Reaction equation

HRID 838652 reaction equation
[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH3:26][Si:27]([N-:28][Si:29]([CH3:30])([CH3:31])[CH3:32])([CH3:33])[CH3:34].[Cl:35][c:36]1[n:37][cH:38][cH:39][c:40]([CH3:42])[n:41]1.[F:1][c:2]1[c:3]([S:9](=[O:10])(=[O:11])[NH:12][c:13]2[cH:14][c:15]([C:16](=[O:17])[O:18][CH2:19][CH3:20])[cH:21][cH:22][c:23]2[F:24])[c:4]([F:8])[cH:5][cH:6][cH:7]1.[Li+:25]>>[F:1][c:2]1[c:3]([S:9](=[O:10])(=[O:11])[NH:12][c:13]2[cH:14][c:15]([C:16](=[O:17])[CH2:42][c:40]3[cH:39][cH:38][n:37][c:36]([Cl:35])[n:41]3)[cH:21][cH:22][c:23]2[F:24])[c:4]([F:8])[cH:5][cH:6][cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 3280088Npc316347HCID 116296072-Chloro-4-methylpyrimidineHCID 57989990Ethyl 3-{[(2,6-difluorophenyl)sulfonyl]amino}-4-fluorobenzoate

Product 1

HCID 57989679N-{5-[(2-Chloro-4-pyrimidinyl)acetyl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

Sources & evidence

ORD record
ord-cffd12a8b14444889d63b1086e6b3297
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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