反应详情

温度

65 °C

190.5 g (1.0 mole) p-toluene sulfonyl chloride, 45 g (0.5 mole) carbohydrazide, 84 g (1.0 mole) sodium bicarbonate and 1000 ml methanol were placed in a 2 liter flask. The mixture was stirred and heated to reflux (65° C) for 90 minutes. Carbon dioxide evolution was complete at this point. The solid product and sodium chloride were filtered off. The material was suspended in water to dissolve the sodium chloride and the residual solid product was filtered off, washed well with water, and dried at 60° C. Yield: 139 g -- Dec. temp. 232° C.

1. temperatureheated
2. filtrationThe solid product and sodium chloride were filtered off
3. dissolutionto dissolve the sodium chloride
4. filtrationthe residual solid product was filtered off
5. washwashed well with water
6. customdried at 60° C