Water → HCID 9840611, compound

HRID 840043Notes

Reaction equation

HRID 840043 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[C:12](Cl)(=[O:24])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23].C(N(CC)CC)C.O>CN(C=O)C>[C:12]([C:9]1[CH:10]=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[CH:6]=[CH:7][C:8]=1[OH:11])(=[O:24])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]

Participants

6

Reactant 4

HCID 962WaterHCID 1983AcetaminophenHCID 8166Dodecanoyl chlorideHCID 8471Triethylamine

Product 1

HCID 9840611HCID 9840611, compoundYield 12%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

An equivalent amount in moles of para-acetylaminophenol and lauroyl chloride are placed in contact at 0° C. in DMF (dilution=15%) in the presence of one molar equivalent of triethylamine. The mixture is allowed to warm to room temperature with stirring and the reaction medium is then poured into water and the product precipitates. It is washed with heptane and then dried under vacuum. The yield is 12%. The elemental analysis is in accordance with the structure.

Workup

  1. customthe product precipitates
  2. washIt is washed with heptane
  3. customdried under vacuum

Sources & evidence

ORD record
ord-05de96853e1a494aa9244e74f4bac646
Source dataset
uspto-grants-2002_04
Patent number
US06365135B1

Reaction notes

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