反应详情

温度

5 °C

3-Chloromethylbenzoyl chloride (1.45 ml) was added to a solution of piperidine (1 ml) in triethylamine (2 ml) and the mixture was stirred under nitrogen at 5° C. for 45 min. Water was added, the product was extracted with dichloromethane and the extract was washed with water, dried over sodium sulphate and evaporated to give 1(3-chloromethylbenzoyl)piperidine (2.32 g) as an oil.

1. extractionthe product was extracted with dichloromethane
2. washthe extract was washed with water
3. dry with materialdried over sodium sulphate
4. customevaporated