Water → 148583-64-6

HRID 840164Notes

Reaction equation

HRID 840164 reaction equation
[Cl:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](Cl)=[O:7].[NH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.O>C(N(CC)CC)C>[Cl:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:7]

Participants

5

Reactant 3

HCID 962WaterHCID 8082PiperidineHCID 27333243-(Chloromethyl)benzoyl chloride

Product 1

HCID 10014405148583-64-6

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Conditions

Temperature
5 °C

Procedure

3-Chloromethylbenzoyl chloride (1.45 ml) was added to a solution of piperidine (1 ml) in triethylamine (2 ml) and the mixture was stirred under nitrogen at 5° C. for 45 min. Water was added, the product was extracted with dichloromethane and the extract was washed with water, dried over sodium sulphate and evaporated to give 1(3-chloromethylbenzoyl)piperidine (2.32 g) as an oil.

Workup

  1. extractionthe product was extracted with dichloromethane
  2. washthe extract was washed with water
  3. dry with materialdried over sodium sulphate
  4. customevaporated

Sources & evidence

ORD record
ord-9c49d763d0b545c889c9a7bf960a8df2
Source dataset
uspto-grants-2002_04
Patent number
US06365604B1

Reaction notes

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