反应详情

温度

55 °C

To a solution of the compound obtained from step m above (0.28 g) in acetonitrile (20 mL) and water (2 mL), 30% perchloric acid (0.4 mL) was added at room temperature. The reaction mixture was heated to 55° C. for 30 minutes. The reaction mixture was then quenched using a sodium bicarbonate solution. The solvents were evaporated at reduced pressure. The residue thus obtained was taken in ethyl acetate and water. The organic layer was separated, washed with water and brine solution, and dried over anhydrous sodium sulphate. The solvent was concentrated under reduced pressure to yield the title compound (0.418 g) as crude mass which was used further without any purification and characterization.

1. customThe reaction mixture was then quenched
2. customThe solvents were evaporated at reduced pressure
3. customThe residue thus obtained
4. customThe organic layer was separated
5. washwashed with water and brine solution
6. dry with materialdried over anhydrous sodium sulphate
7. concentrationThe solvent was concentrated under reduced pressure