反应详情

温度

-10 °C

Acetone (40 ml) is stirred and 5-carboxyphthalide (2 g ,0.01 1 mol) are added at about 20° C. The mixture is cooled to −10° C. and ethyl chloroformate (1.18 ml, 0.012 mol) is added. At the end of the addition, a solution of triethylamine (1.56 ml ,0.011 mol) in acetone (3.50 ml) is added keeping the temperature of the mixture at or below −10° C. The temperature of the mixture is allowed to rise to 10-13° C. and, after 30 minutes, it is brought to −10° C. and a solution of 2-amino-2-methyl-1-propanol (3.0 g ,0.034 mol) in acetone (5 ml) is quickly added to the mixture. The temperature is allowed to rise to 15-20° C., whereby the reaction is completed as it may be verified by HPLC. To the mixture thus obtained, cooled to −5° C., thionyl chloride (2.5 ml, 0.034 mol) is added, the temperature is allowed to rise to about 20° C. and after 30 minutes the ring closure is completed. The reaction mixture is concentrated in vacuo leaving a residue, which is treated with water (20 ml). The mixture is concentrated again and a further amount of water (10 ml) is added to the residue, the pH is made basic by addition of 25% ammonia and the mixture is cooled to 5° C. The product is filtered off, washed with water and dried in vacuo. Yield: 1.70 g. Total yield: 66.8%.

1. additionAt the end of the addition
2. custombelow −10° C
3. customis brought to −10° C.
4. customto rise to 15-20° C.
5. customTo the mixture thus obtained
6. temperaturecooled to −5° C.
7. waitto rise to about 20° C. and after 30 minutes
8. concentrationThe reaction mixture is concentrated in vacuo
9. customleaving a residue, which
10. concentrationThe mixture is concentrated again
11. additiona further amount of water (10 ml) is added to the residue
12. additionthe pH is made basic by addition of 25% ammonia
13. temperaturethe mixture is cooled to 5° C
14. filtrationThe product is filtered off
15. washwashed with water
16. customdried in vacuo