HCID 67183523, compound → Ethyl 3-[4-(5-methylpyridin-2-yl)phenyl]propanoate

HRID 84040Notes

Reaction equation

HRID 84040 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11](/[CH:14]=[CH:15]/[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:10][CH:9]=2)=[N:6][CH:7]=1.[H][H]>[Pd].O1CCCC1>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:10][CH:9]=2)=[N:6][CH:7]=1

Participants

5

Reactant 2

HCID 67183523HCID 67183523, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67182542Ethyl 3-[4-(5-methylpyridin-2-yl)phenyl]propanoate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

10% Palladium on charcoal (0.8 g) was added to a solution of the compound obtained from step b above (1.8 g) in tetrahydrofuran (15 mL) at room temperature, and hydrogen was supplied at 50 psi in a Paar apparatus for 4 hours. The reaction mixture was filtered through a celite pad and concentrated to afford the title compound (1.8 g).

Workup

  1. filtrationThe reaction mixture was filtered through a celite pad
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-d7cb2973bd8a4b6fb9554f0893717899
Source dataset
uspto-grants-2014_09
Patent number
US08846910B2

Reaction notes

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