Dichloromethane → HCID 22622478, compound

HRID 840425Notes

Reaction equation

HRID 840425 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([C:13](O)=[O:14])[C:6]2[C:11]([CH:12]=1)=[CH:10][CH:9]=[CH:8][CH:7]=2.C(Cl)[Cl:19].C(Cl)(=O)C(Cl)=O>CN(C=O)C>[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([C:13]([Cl:19])=[O:14])[C:6]2[C:11]([CH:12]=1)=[CH:10][CH:9]=[CH:8][CH:7]=2

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 22622244HCID 22622244, compound

Product 1

HCID 22622478HCID 22622478, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture containing 3-trifluoromethyl-1-naphthoic acid (0.10 g) and dry DCM (5 mL) was treated with oxalyl chloride (0.065 g) at 25° C. A catalytic amount of DMF was added, the mixture stirred for 4 hours, then the DCM was removed in vacuo. The solid residue was re-dissolved in dry DCM and used without further purification.

Workup

  1. customthe DCM was removed in vacuo
  2. dissolutionThe solid residue was re-dissolved in dry DCM
  3. customused without further purification

Sources & evidence

ORD record
ord-e94a75f9298047098b4950ea18f2d0fb
Source dataset
uspto-grants-2002_04
Patent number
US06365602B1

Reaction notes

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