HRID840625
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 75 °C
PROCEDURE
实验过程
Palladium (II) acetate (81 mg, 0.036 mmol) was added into a mixture of 4′-(2-benzyl-benzo[b]thiophen-3-yl)-3,5-dibromo-biphenyl-4-ol (1.0 g, 1.82 mmol), 4-methoxy-benzeneboronic acid, barium hydroxide (0.93 g, 5.46 mmol), 1,2-dimethoxyethane (10 mL), and water (10 mL). The mixture was stirred at 75° C. for 10 hours, poured into water, and extracted with ethyl ether. The organic extracts were dried over MgSO4. Evaporation and purification by flash chromatography on silica gel (hexanes/EtAOc 4:1) gave 4,4″-dimethoxy-5′-{4-[2-(phenylmethyl)benzo[b]thien-3-yl]phenyl}[1,1′;3′,1″-terphenyl]-2′-ol as a yellow solid (0.45 g,): mp 80-82; MS m/e 604 (M+);
WORKUP
后处理
- extractionextracted with ethyl ether
- dry with materialThe organic extracts were dried over MgSO4
- customEvaporation and purification by flash chromatography on silica gel (hexanes/EtAOc 4:1)