Anisole → HCID 22620003, compound

HRID 840647Notes

Reaction equation

HRID 840647 reaction equation
C([NH:5][S:6]([C:9]1[C:10]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][N:22]([CH2:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[C:23](=[O:30])[CH2:24][C:25]3[S:26][CH:27]=[CH:28][CH:29]=3)=[C:17]([Cl:38])[CH:16]=2)=[CH:11][CH:12]=[CH:13][CH:14]=1)(=[O:8])=[O:7])(C)(C)C.C1(OC)C=CC=CC=1>FC(F)(F)C(O)=O>[CH2:31]([N:22]([CH2:21][C:18]1[CH:19]=[CH:20][C:15]([C:10]2[C:9]([S:6]([NH2:5])(=[O:8])=[O:7])=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:16][C:17]=1[Cl:38])[C:23](=[O:30])[CH2:24][C:25]1[S:26][CH:27]=[CH:28][CH:29]=1)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Participants

4

Reactant 2

HCID 7519AnisoleHCID 70129779HCID 70129779, compound

Product 1

HCID 22620003HCID 22620003, compoundYield 127,516.5%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

510 mg of 4′-{[benzyl-(2-thiophen-2-ylacetyl)amino]methyl}-3′-chloro-biphenyl-2-sulfonic acid t-butylamide and 110 μl of anisole are allowed to stand at RT for 18 h in 3 ml of trifluoroacetic acid. The volatile constituents are then removed in vacuo, the residue is taken up in 5 ml of toluene and volatile constituents are again removed in vacuo. 586 g of a colorless oil are obtained, which is used further without purification.

Workup

  1. customThe volatile constituents are then removed in vacuo
  2. customvolatile constituents are again removed in vacuo

Sources & evidence

ORD record
ord-f15fb749997e493ba4347ba4f5100017
Source dataset
uspto-grants-2002_04
Patent number
US06369069B1

Reaction notes

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