Sodium hydride → HCID 69968776, compound

HRID 840731Notes

Reaction equation

HRID 840731 reaction equation
[CH3:1][O:2][C:3]1[O:7][C:6](=[O:8])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16](=[O:21])[CH2:17][CH2:18][CH2:19]Cl)=[C:11]([CH3:22])[CH:10]=2)[N:4]=1.[H-].[Na+]>O1CCOCC1>[CH3:1][O:2][C:3]1[O:7][C:6](=[O:8])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH2:19][CH2:18][CH2:17][C:16]3=[O:21])=[C:11]([CH3:22])[CH:10]=2)[N:4]=1

Participants

4

Reactant 2

HCID 24758Sodium hydrideHCID 22620261HCID 22620261, compound

Product 1

HCID 69968776HCID 69968776, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The latter compound was prepared by reacting 5-methoxy-3-(4-(4-chlorobutanoylamino)-3-methylphenyl)-3H-(1,3,4)oxadiazol-2-one with sodium hydride in dioxane at room temperature and purifying the crude product by column chromatography (silica gel, methylene chloride:methanol=98:2).

Workup

  1. customThe latter compound was prepared
  2. customat room temperature
  3. custompurifying the crude product by column chromatography (silica gel, methylene chloride:methanol=98:2)

Sources & evidence

ORD record
ord-51ec78ecbb92488d8afbe14bfd035df1
Source dataset
uspto-grants-2002_04
Patent number
US06369088B2

Reaction notes

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