Hydrochloric Acid → HCID 70091156, compound

HRID 840792Notes

Reaction equation

HRID 840792 reaction equation
[CH2:1]([C@@H:8]1[N:13](C(OCC2C=CC=CC=2)=O)[CH:12]=[CH:11][N:10]([CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])[C:9]1=[O:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>C(O)C.[Pd]>[CH2:1]([C@@H:8]1[NH:13][CH:12]=[CH:11][N:10]([CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])[C:9]1=[O:30])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 70091218HCID 70091218, compound

Product 1

HCID 70091156HCID 70091156, compoundYield 167.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of the compound of Example 29 (1 g, 2.4 mmol) in absolute ethanol (10 mL) was treated with 5%Pd/C (200 mg) and concentrated HCl (2 mL). The mixture was hydrogenated at 40 p.s.i. for 2 hours. The mixture was filtered through Celite to remove the catalyst and the filtrate was evaporated under reduced pressure to give the title compound (1.1 g, 81% yield).

Workup

  1. filtrationThe mixture was filtered through Celite
  2. customto remove the catalyst
  3. customthe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-b49854927d534308816012e78fa944b0
Source dataset
uspto-grants-2002_04
Patent number
US06369063B1

Reaction notes

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