Chloride → HCID 178466659, compound

HRID 841124Notes

Reaction equation

HRID 841124 reaction equation
[C:1]([C:4]1[C:5]([C:23](=[O:25])[CH3:24])=[C:6]([OH:22])[C:7](=[CH:20][CH:21]=1)[C:8]([O:10]CCOCCOCCO)=[O:9])(=[O:3])[CH3:2].[Cl-].C(OC1C(=CC=CC=1)C(O)=O)(=O)C.[CH2:40]([OH:44])[CH:41]([OH:43])[CH3:42]>>[CH2:40]([OH:44])[CH:41]([OH:43])[CH3:42].[C:1]([C:4]1[C:5]([C:23](=[O:25])[CH3:24])=[C:6]([OH:22])[C:7](=[CH:20][CH:21]=1)[C:8]([O-:10])=[O:9])(=[O:3])[CH3:2]

Participants

5

Reactant 4

HCID 312ChlorideHCID 1030Propylene GlycolHCID 2244AspirinHCID 131723178HCID 131723178, compound

Product 1

HCID 178466659HCID 178466659, compound

Procedure

The compound (V) was prepared according to the procedure described in Example 1 for the synthesis of (XIX), starting from 5,6 g of the chloride of acetylsalicylic acid, 3.8 ml of TEA and 1.06 g of 1.2-propanediol. The product was purified by flash chromatography utilizing an eluent mix constituted by ethylether/hexane 6:4 (v/v). The intermediate fractions were collected, the solvent was evaporated under reduced pressure and 0.55 g of 1.2-propanediol-bis-acetylsalicylate (V) were obtained.

Workup

  1. customThe compound (V) was prepared
  2. customThe product was purified by flash chromatography
  3. additionmix
  4. customThe intermediate fractions were collected
  5. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-846ffa82128149de950f7fd61b1ba73b
Source dataset
uspto-grants-2002_04
Patent number
US06369260B1

Reaction notes

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