反应详情

A solution of 5.2 g 4-oxo-decanoic acid, 13.5 g geraniol, 17.5 g N,N′-dicyclohexyl-carbodiimide and 1.0 g 4-pyrrolidinopyridine in 250 ml of dichloromethane was stirred for 24 hours at room temperature. The precipitate was filtered off, the filtrate was diluted with ether, washed with aqueous hydrochloric acid, saturated NaHCO3 and brine. The organic phase was dried, filtered and evaporated to dryness. The resulting oil-cristall mixture was purified by chromatography to yield 19.7 g of a colourless oil.

1. filtrationThe precipitate was filtered off
2. additionthe filtrate was diluted with ether
3. washwashed with aqueous hydrochloric acid, saturated NaHCO3 and brine
4. customThe organic phase was dried
5. filtrationfiltered
6. customevaporated to dryness
7. customThe resulting oil-cristall mixture was purified by chromatography