Sodium borohydride → HCID 22620843, compound

HRID 841156Notes

Reaction equation

HRID 841156 reaction equation
[BH4-].[Na+].[O:3]=[C:4]([CH3:33])[CH2:5][CH2:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([S:16]([C:19]2[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:32])[CH2:27][CH2:28][C:29](=[O:31])[CH3:30])=[CH:21][CH:20]=2)(=[O:18])=[O:17])=[CH:12][CH:11]=1)=[O:8]>CO.C1COCC1>[OH:31][CH:29]([CH3:30])[CH2:28][CH2:27][C:26]([NH:25][C:22]1[CH:21]=[CH:20][C:19]([S:16]([C:13]2[CH:12]=[CH:11][C:10]([NH:9][C:7](=[O:8])[CH2:6][CH2:5][CH:4]([OH:3])[CH3:33])=[CH:15][CH:14]=2)(=[O:18])=[O:17])=[CH:24][CH:23]=1)=[O:32]

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 22620849HCID 22620849, compound

Product 1

HCID 22620843HCID 22620843, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of sodium borohydride in methanol was cooled to 5° C. A solution of 4-oxo-pentanoic acid {4-[4-(4-oxo-pentanoylamino)-benzenesulfonyl]-phenyl}-amide in THF was added and the resulting reaction mixture was stirred at room temperature. After workup and purification, the product was obtained as a colourless solid.

Workup

  1. customthe resulting reaction mixture
  2. customAfter workup and purification
  3. customthe product was obtained as a colourless solid

Sources & evidence

ORD record
ord-52a2fe678352490b8f96060ced020a95
Source dataset
uspto-grants-2002_04
Patent number
US06369248B1

Reaction notes

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