反应详情

A mixture of 62.7 ml (500 mmol) of phenylethylamine, 70.4 ml (506 mmol) of triethylamine and 150 ml of dichloromethane was admixed dropwise at 0° C. with a solution of 109.2 g of 2-bromobenzoyl chloride in 50 ml of dichloromethane with good stirring at such a rate that the temperature did not exceed 30° C. Subsequently, the mixture was stirred at room temperature for a further 1 h. The colorless solid thus obtained was filtered off with suction, washed three times with 200 ml of dichloromethane and dried under reduced pressure. The yield at a purity of approx. 99.0% was 138.2 g (453 mmol), 90.7% of theory.

1. customdid not exceed 30° C
2. stirringSubsequently, the mixture was stirred at room temperature for a further 1 h
3. customThe colorless solid thus obtained
4. filtrationwas filtered off with suction
5. washwashed three times with 200 ml of dichloromethane
6. customdried under reduced pressure
7. customThe yield at a purity of approx. 99.0%