反应详情

3-Amino-6-methoxypyridine (12.41 g) and diethyl ethoxymethylene malonate (20.2 ml) in Dowtherm A (400 ml) was heated at reflux, under argon for 1 h. The cooled reaction mixture was poured onto pentane (1 litre). The precipiated solid was collected by filration, washing with pentane. Drying afforded the title compound (24.78 g, crude).

1. temperatureat reflux, under argon for 1 h
2. customThe cooled reaction mixture
3. additionwas poured onto pentane (1 litre)
4. customThe precipiated solid was collected by filration
5. washwashing with pentane
6. customDrying