Hydrochloric Acid → HCID 22617787, compound

HRID 842073Notes

Reaction equation

HRID 842073 reaction equation
[CH2:1]([N:8]([CH2:29][CH3:30])[C:9](=[O:28])[CH2:10][N:11]1[C:19](=[O:20])[N:18]([CH3:21])[C:17]2[C:12]1=[N:13][C:14]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[N:15][CH:16]=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:31]>C(O)C>[ClH:31].[CH2:1]([N:8]([CH2:29][CH3:30])[C:9](=[O:28])[CH2:10][N:11]1[C:19](=[O:20])[N:18]([CH3:21])[C:17]2[C:12]1=[N:13][C:14]([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)=[N:15][CH:16]=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 6433109Emapunil

Product 1

HCID 22617787HCID 22617787, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a mixture of N-benzyl-N-ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-9H-purin-9-acetamide (0.8 g) obtained in Example 146 and ethanol (15 ml) is added 30% hydrochloric acid in ethanol (15 ml) at 80° C., and the mixture is stirred for 30 minutes. The reaction mixture is cooled to room temperature, and the precipitates are collected by filtration, and washed with ethanol to give the desired compound (0.85 g).

Workup

  1. filtrationthe precipitates are collected by filtration
  2. washwashed with ethanol

Sources & evidence

ORD record
ord-88a8a3c6fdba4222a3d86421b74442b2
Source dataset
uspto-grants-2002_04
Patent number
US06372740B1

Reaction notes

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