Triethylamine → HCID 22618277, compound

HRID 842118Notes

Reaction equation

HRID 842118 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[CH2:4][C:5]1[O:6][C:7]2[C:13]([CH2:14][CH2:15][CH2:16][OH:17])=[CH:12][CH:11]=[CH:10][C:8]=2[N:9]=1.[CH3:22][S:23](Cl)(=[O:25])=[O:24].C(N(CC)CC)C>CCOCC>[Cl:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[CH2:4][C:5]1[O:6][C:7]2[C:13]([CH2:14][CH2:15][CH2:16][O:17][S:23]([CH3:22])(=[O:25])=[O:24])=[CH:12][CH:11]=[CH:10][C:8]=2[N:9]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 9944208HCID 9944208, compound

Product 1

HCID 22618277HCID 22618277, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 2-(2-chlorobenzyl)-7-(3-hydroxy-1-propyl)benzoxazole (10 g, 0.033 mole) in ether (50 ml) was treated with methanesulfonyl chloride (4.4 g, 0.037 mol) and triethylamine 3.7 g, 0.037 mol). After stirring for 1 hour, the triethylamine hydrochloride was filtered and the ether was evaporated to give the title compound which was pure by TLC.

Workup

  1. filtrationthe triethylamine hydrochloride was filtered
  2. customthe ether was evaporated

Sources & evidence

ORD record
ord-c539ac5faece419293130ac31efb272b
Source dataset
uspto-grants-2002_04
Patent number
US06372770B1

Reaction notes

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