Trifluoroacetic acid → Aminocaproic Acid, Benzyl Ester

HRID 842429Notes

Reaction equation

HRID 842429 reaction equation
C([NH:8][CH:9]([CH2:20][CH2:21][CH2:22][CH3:23])[C:10]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:11])(OC(C)(C)C)=O.FC(F)(F)C(O)=O>ClCCl>[NH2:8][CH:9]([CH2:20][CH2:21][CH2:22][CH3:23])[C:10]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:11]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 14420167HCID 14420167, compound

Product 1

HCID 14083108Aminocaproic Acid, Benzyl EsterYield 151.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To N-Boc-aminocaproic acid, benzyl ester (1.125 g, 3.50 mmol) in dichloromethane (4 ml) was added trifluoroacetic acid (8 ml) and the mixture stirred at room temperature for 10 minutes. The solvents were removed in vacuo to give the title compound (1.17 g, 100%) as an oil.

Workup

  1. customThe solvents were removed in vacuo

Sources & evidence

ORD record
ord-074dde48283b48059e07493826c36d43
Source dataset
uspto-grants-2002_04
Patent number
US06375926B1

Reaction notes

Loading…