Iodine → HCID 11323077, compound

To a solution of optically active 5 (16.8 g, 120 mmol), in methylene chloride (200 mL) and water (400 mL), was added NaHCO3 (20.1 g, 240 mmol), KI (120 g, 0.720 mmol) and iodine (91.0 g, 0.360 mmol). The resulting mixture was protected from light and stirred for 24 h. The solution was cooled (0° C.) and sodium thiosulfate was carefully added until the dark iodine color disappeared. This was extracted with diethyl ether (4×300 mL). The combined organics were dried (MgSO4) and the volatiles were removed in vacuo to give a yellowish solid (27.8 g, 87% yield). This was carried onto the next step without further purification. Rf 0.33 (ethyl acetate/hexane 1:9); m.p. 99-100° C.; 1H NMR (300 MHz, CDCl3) δ 4.86 (dd, J=3.6, 5.9, 1H), 4.35-4.38 (m, 1H), 2.90 (m, 1H), 2.63-2.73 (m, 1H), 2.49-2.52 (m, 1H), 2.20-2.36 (m, 2H), 1.95-2.00 (m, 1H). 1.38 (d, J=7.2, 3H); 13C NMR (75 MHz, CDCl3) δ 178.2, 81.6, 43.8, 34.3, 29.3, 27.8, 19.5, 19.1; MS (EI) m/z 266 (M+, 4), 139 ([M-I]+, 80), 95 (100), 79 (16), 67 (26), 55 (29); [α]D−3.60° (c=2.22, CHCl3).

1. extractionThis was extracted with diethyl ether (4×300 mL)
2. dry with materialThe combined organics were dried (MgSO4)
3. customthe volatiles were removed in vacuo

ORD record

ord-3e249fde05544758a724430e504ebe28

Source dataset

uspto-grants-2002_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06375943B1