Hydrochloric Acid → HCID 11450620, compound

HRID 842540Notes

Reaction equation

HRID 842540 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH:7]=[CH:8][N:9]2[N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[NH:14][C:13]2=[O:23])=[CH:5][CH:4]=1.[C:24](=O)([O-])[O-].[K+].[K+].CI.Cl>O.C(#N)C>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH:7]=[CH:8][N:9]2[N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[N:14]([CH3:24])[C:13]2=[O:23])=[CH:5][CH:4]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 11404582HCID 11404582, compound

Product 1

HCID 11450620HCID 11450620, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

A mixture of 0.2 g 1B, 0.25 g potassium carbonate and 15 ml acetonitrile is treated with 0.2 g methyl iodide at room temperature. After stirring over night the mixture is poured into water, acidified with aqueous hydrochloric acid and extracted with ethyl acetate.

Workup

  1. extractionextracted with ethyl acetate

Sources & evidence

ORD record
ord-e0becb9bc71544a3a1c8cf6797d4864a
Source dataset
uspto-grants-2002_04
Patent number
US06376426B1

Reaction notes

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